Role of Multiparametric MRI in Diagnosis of Prostate Cancer

  • Dr. Manoj Mathur Professor, Department of Radiodiagnosis, Government Medical College Patiala, Pubjab, India
  • Dr. Rohan Bains Junior Resident, Department of Radiodiagnosis, Government Medical College Patiala, Pubjab, India
  • Dr. Ramanpreet Kaur Junior Resident, Department of Pathology, Government Medical College Patiala, Pubjab, India
  • Dr. Rajesh K. Badhan Senior Resident, Department of Radiodiagnosis, Government Medical College Patiala, Pubjab, India
  • Dr. Sachin Kuchya Junior Resident, Department of Radiodiagnosis, Government Medical College Patiala, Pubjab, India
  • Dr. Dimple Mittal Junior Resident, Department of Radiodiagnosis, Government Medical College Patiala, Pubjab, India
Keywords: T2 weighted imaging, T1 weighted imaging, Diffusion weighted imaging, Dynamic contrast enhanced imaging, MR spectroscopy

Abstract

Aims: The main objectives of our study were to evaluate the role of Multiparametric MRI (mp-MRI) in diagnosis of carcinoma prostate and to compare the various MRI sequences used in MRI in evaluating carcinoma prostate with histopathological diagnosis kept as reference standard.

Materials and Methods: This prospective cross-sectional study of 40 patients was performed by using various sequences used in mp-MRI i.e. T2 weighted imaging (T2WI), Diffusion Weighted Imaging (DWI), Magnetic Resonance Spectroscopy (MRS) and Dynamic Contrast Enhanced study (DCE). Findings of mp-MRI sequences were compared with histopathological diagnosis. Statistical analysiswasperformed using SPSS computer statistical program for window release 16.

Results: Sensitivity, specificity, positive predictive value (PPV), negative predictive value (NPV) of DCE in diagnosing carcinoma prostate were 88.89%, 50.00%, 94.12% and 33.33% respectively where as sensitivities, specificities, PPVs, NPVs of DWI and MRS were same in our study i.e. 94.44%, 75.00%, 97.14% and 60.00% respectively. Overall sensitivity, specificity, PPV, NPV of mp-MRI by combining these sequences were found to be 97.22%, 75%, 97.22% and 75% respectively. Diagnostic accuracies of DWI, DCE and MRS were 92.5%, 85% and 92.5% respectively and overall diagnostic accuracy after combining these sequences in mp-MRI was 95%.

Conclusions: mp-MRI including all the sequences has very good role in evaluation of carcinoma prostate. Diagnostic accuracy of mp-MRI increases when all sequences used together to assess prostatic lesions, so all the sequences should be used together in prostate cancer evaluation rather than using individual sequences.

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Published
2019-09-30
How to Cite
Mathur, M., Bains, R., Kaur, R., K. Badhan, R., Kuchya, S., & Mittal, D. (2019). Role of Multiparametric MRI in Diagnosis of Prostate Cancer. Tropical Journal of Radiology and Imaging of Siddharth Health Research and Social Welfare Society, 1(1), 11-19. Retrieved from https://radiology.medresearch.in/index.php/tjri/article/view/5
Issue
Vol 1 No 1 (2019): JUL-SEP
Section
Original Article